HCID 178441461, compound → HCID 178441459, compound

Participants

Reaction Steps

A mixture of ethyl 2-butyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]benzimidazole-7-acetate (0.28 g) in 1N NaOH (1.5 ml) and methanol (5 ml) was heated for two hours under reflux. The reaction mixture was concentrated, which was neutralized with 1N-HCl. Crystals separated out were collected by filtration and purified by column chromatography on silica gel to afford colorless crystals (0.12 g, 46%), m.p. 170°-171° C.

Provenance & Evidence