2-Ethylhexanoic Acid → HCID 178441466, compound

Participants

Reaction Steps

A mixture of 2-butyl-1-[(2'-cyanobiphenyl-4-yl)methyl]-7-methoxymethylbenzimidazole (0.6 g) and trimethyltin azide (1.2 g) in toluene (12 ml) was heated for 3 days under reflux in toluene (12 ml). The solvent was distilled off. To the residue was added 1N-HCl (8 ml) and the mixture was stirred for a while, followed by extraction with ethyl acetate. The organic layer was washed with water and dried, then the solvent was distilled off. The residue was purified by column chromatography on silica gel to give an oil. The product was dissolved in ethyl acetate, to which was added a methanol solution of sodium salt of 2-ethyl hexanoic acid (0.25 g). The mixture was concentrated. Crystals separated out were recrystallized from toluene-ethyl acetate to afford colorless crystals (0.22 g, 31%), m.p.175°-178° C.

Provenance & Evidence