Hydrochloric Acid → HCID 178494643, compound

Participants

Reaction Steps

A mixture of methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-methoxymethylbenzimidazole-7-carboxylate (0.4 g) and trimethyltin azide (1.0 g) in toluene (10 ml) was refluxed for 49 hours. The reaction solution was concentrated to dryness to give a residue and the residue was dissolved in methanol (6 ml) and 1N-HCl (6 ml). The solution was allowed to stir for 3 hours and concentrated to dryness to give a residue. The residue was dissolved in CH2Cl2 -H2O and the mixture was made neutral with 1N-NaOH. The organic layer was washed with H2O, dried and concentrated to dryness to give a residue, which was purified by column chromatography on silica gel to give a crystalline product. Recrystallization from ethyl acetate-isopropylether gave colorless needles (0.3 g, 68%).

Provenance & Evidence