Potassium Carbonate → 2-Cyano-2-fluoromethoxyiminoacetamide

Beteiligte Stoffe

Reaktionsschritte

2-Cyano-2-hydroxyiminoacetamide (22.6 g) was dissolved in dimethyl sulfoxide (100 ml). Potassium carbonate (55.2 g) was added under stirring at room temperature, followed by stirring for further 20 minutes. Thereafter, a solution of fluorobromomethane (27 g) in dimethylformamide (20 ml) was added. The resulting mixture was stirred for 20 hours at room temperature and then allowed to cool down. The reaction mixture was added to ice water (1 l), followed by extraction twice with 150 ml of ethyl acetate. The organic layer was washed twice with saturated saline. Anhydrous magnesium sulfate was added to the thus-washed organic layer to dry the same. The solvent was thereafter distilled off. The residue was washed with ethyl ether and dried to obtain the target product (14.4 g).

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