Water → HCID 19815306, compound

HRID 653917Notes

Reaction equation

HRID 653917 reaction equation
[C:1]([C:3]1[CH:29]=[CH:28][CH:27]=[CH:26][C:4]=1[CH2:5][O:6][C:7]1[CH:25]=[CH:24][C:10]([CH2:11][N:12]2[C:16]([CH2:17][OH:18])=[C:15]([Cl:19])[N:14]=[C:13]2[CH2:20][CH2:21][CH2:22][CH3:23])=[CH:9][CH:8]=1)#[N:2].[CH3:30]C(C)([O-])C.[K+].CI.O>CS(C)=O>[C:1]([C:3]1[CH:29]=[CH:28][CH:27]=[CH:26][C:4]=1[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:11][N:12]2[C:16]([CH2:17][O:18][CH3:30])=[C:15]([Cl:19])[N:14]=[C:13]2[CH2:20][CH2:21][CH2:22][CH3:23])=[CH:24][CH:25]=1)#[N:2]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 19815336HCID 19815336, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 19815306HCID 19815306, compoundYield 56.7%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

To a solution of 0.29 g of 1-[4-(2-cyanobenzyloxy)benzyl]-2-butyl-4-chloro-5-hydroxymethylimidazole in 8.0 mL of dimethyl sulfoxide at 25° was added 0.93 g of potassium t-butoxide followed by 0.060 mL of methyl iodide. The reaction mixture was stirred at 25° for 2.5 hours and then was poured into water. The aqueous emulsion was extracted with ethyl acetate; the organic phases were combined and washed with water and brine, dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. Column chromatography on silica gel (elution: 5-25% ethyl acetate/benzene) furnished 0.17 g of 1-[4-(2-cyanobenzyloxy)benzyl]-2-butyl-4-chloro-5-methoxymethylimidazole; NWR (200 MHz, CDCl3): δ7.72-7.57 (m, 3H); 7.43 (m, 1H); 6.94 (s, 4h); 5.22 (s, 2H); 5.04 (s, 2H); 4.27 (s, 2H); 3.26 (s, 3H): 2.56 (t, 2H); 1.65 (quint., 2H); 1.33 (sext., 2H); 0.88 (t, 3H).

Workup

  1. extractionThe aqueous emulsion was extracted with ethyl acetate
  2. washwashed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-5c4c666e4b6540cfa70a77a757109746
Source dataset
uspto-grants-1992_07
Patent number
US05128355

Reaction notes

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