Tributylstannane → 3-(Tributylstannyl)-2-propenoic acid phenylmethyl ester

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a stirring mixture of 2-propynoic acid phenylmethyl ester (2.46 g, 15.4 mmol) and tributyltin hydride (3.89 mL, 14.9 mmol, 97% purity) was added 2,2'-azobisisobutyronitrile (99.4 mg) and the reaction mixture was slowly warmed to 65° C. After stirring for 8 h at 65° C., the cooled reaction mixture was purified by flash chromatography, eluting with a mixture of hexane and EtOAc (50:1) to give 3-(tributylstannyl)-2-propenoic acid phenylmethyl ester (4.80 g, 10.65 mmol) as a mixture of E and Z isomers, in 69% yield.

Herkunft & Nachweise