反应详情

A mixture consisting of 53.0 g of 3-(4,6-dimethoxy-2-pyrimidinyloxy)-2-formylpyridine, 30.7 g of ethyl orthoformate, 0.48 g of ammonium chloride and 500 ml of methanol was heated under stirring at a reflux point for 5 hours. After the reaction mixture was cooled to room temperature, the precipitate was filtered off. The filtrate was concentrated under reduced pressure so that 56.1 g of 3-(4,6-dimethoxy-2-pyrimidinyloxy-2-pyridinecarboxaldehyde dimethylacetal were obtained (yield: 90%). A purified product was obtained by chromatography on a silica gel column.

1. temperaturewas heated
2. filtrationthe precipitate was filtered off
3. concentrationThe filtrate was concentrated under reduced pressure so that 56.1 g of 3-(4,6-dimethoxy-2-pyrimidinyloxy-2-pyridinecarboxaldehyde dimethylacetal
4. customwere obtained (yield: 90%)
5. customA purified product was obtained by chromatography on a silica gel column