Sodium Hydroxide → HCID 15057597, compound

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Reaction Steps

2.68 g (10.1 mmol) of 2-[N-(2,4-difluorophenyl)sulfamoyl]-acetic acid methyl ester is dissolved in 30 ml of dioxane, 15 ml of 2N sodium hydroxide solution is added and stirred for 30 minutes at room temperature. The reaction solution is then evaporated to dryness, the residue is dissolved in some water, the solution is again concentrated by evaporation, the residue is dissolved in 30 ml of water, acidified with 2N hydrochloric acid and the product is extracted with ethyl acetate. The organic phase is dried on sodium sulfate, filtered and evaporated to dryness in a vacuum The crude product is recrystallized from ether/hexane 1:1. 1.55 g (6.17 mmol)=61.1% of the theoretical yield is obtained as a crystallizate, melting point 110-111.5° C.

Provenance & Evidence