反应详情

1.37 g (4.8 mmol) of 2-[N-(2,4,6-trifluorophenyl)sulfamoyl]-acetic acid methyl ester is dissolved in 15 ml of dioxane, 7.5 ml of 2N sodium hydroxide solution is added and it is stirred for one hour at room temperature. The solution is then evaporated to dryness, the residue is dissolved in water, the solution is acidified with 2N hydrochloric acid and extracted twice with ethyl acetate. The ethyl acetate extract is dried on magnesium sulfate, filtered and evaporated to dryness. The residue is crystallized from diethyl ether. 1.12 g (4.16 mmol)=86.68% of the theoretical yield is obtained. Melting point 126-127° C.

1. customThe solution is then evaporated to dryness
2. dissolutionthe residue is dissolved in water
3. extractionextracted twice with ethyl acetate
4. extractionThe ethyl acetate extract
5. customis dried on magnesium sulfate
6. filtrationfiltered
7. customevaporated to dryness
8. customThe residue is crystallized from diethyl ether
9. custom1.12 g (4.16 mmol)=86.68% of the theoretical yield
10. customis obtained