反应详情

2.22 g (6 mmol) of 2-[N-(2,4,6-trifluorophenyl)sulfamoyl]-acetic acid-[2-hydroxy-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethyl-amide] is dissolved in a mixture of 10 ml of methanol and 5 ml of water, about 100 mg of cation exchanger Amberlyst 15 is added and it is warmed to boiling temperature in 1 hour. The ion exchanger is then filtered off and the filtrate is evaporated to dryness in a vacuum. 1.94 g (5.24 mmol) =87.3% of the theoretical yield of the product is obtained as an amorphous solid.

1. additionis added
2. temperatureit is warmed
3. customin 1 hour
4. filtrationThe ion exchanger is then filtered off
5. customthe filtrate is evaporated to dryness in a vacuum
6. custom1.94 g (5.24 mmol) =87.3% of the theoretical yield of the product is obtained as an amorphous solid