反应详情

2.53 g (5 mmol) of 3-[N-(4-fluoro-2-trifluoromethylphenyl)sulfamoyl]-benzoic acid-[2-hydroxy-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethylamide] is dissolved in 20 ml of methanol/water 1:1, about 100 mg of cation exchanger Amberlyst 15 is added and warmed to boiling temperature in 1 hour. The ion exchanger is then filtered off and the filtrate is evaporated to dryness in a vacuum. 1.94 g (4.18 mmol)=83.5% of the theoretical yield of the product is obtained as an amorphous solid.

1. additionis added
2. temperaturewarmed
3. customin 1 hour
4. filtrationThe ion exchanger is then filtered off
5. customthe filtrate is evaporated to dryness in a vacuum
6. custom1.94 g (4.18 mmol)=83.5% of the theoretical yield of the product is obtained as an amorphous solid