Sodium Hydroxide → HCID 15057640, compound

Participants

Reaction Conditions

Reaction Steps

6.05 g (15 mmol) of 5-[N-(2,4,6-trifluorophenyl)sulfamoyl]-isophthalic acid dimethyl ester is dissolved in 60 ml of dioxane, 15 ml (30 mmol) of 2N NaOH is added and it is stirred for 3 hours at 50° C. The solution is then concentrated by evaporation to about 15 ml at reduced pressure, acidified with 2N hydrochloric acid and the resulting solid precipitate is suctioned off. The filter residue is dissolved in ethyl acetate, the solution is shaken out twice with water, dried on sodium sulfate, filtered and evaporated to dryness. 4.8 g (12.78 mmol)=85.22% of the theoretical yield is obtained as an amorphous solid.

Provenance & Evidence