Benzyl Bromide → HCID 15057657, compound

Participants

Reaction Steps

0.65 g (28 mmol) of sodium is dissolved in 35 ml of dry ethanol, 5.96 g (23 mmol) of 2-bromo-4-fluoro-6-(trifluoromethyl)-phenol is added and it is stirred for 20 minutes at room temperature, 7.17 g (42 mmol) of benzyl bromide is added and refluxed for 1 hour. Sodium bromide precipitates out crystalline from the solution The hot solution is filtered, the filtrate is evaporated to dryness and the residue is chromatographed on silica gel 60 with dichloromethane/hexane. 6.29 g (18 mmol) =78.3% of the theoretical yield is obtained as a predominantly crystalline solid.

Provenance & Evidence