HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-3-(trifluoromethyl)aniline → 2-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]acetic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-3-(trifluoromethyl)aniline | HCID 75377 | — |
| Reactant | Methyl (chlorosulfonyl)acetate | HCID 11435213 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 2-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]acetic Acid Methyl Ester | HCID 54294492 | — |
Reaction Steps
Analogously to the instructions for example 7, 5 g (27.64 mmol) of 4-fluoro-3-(trifluoromethyl)-aniline in 25 ml of dry pyridine is reacted with 4.82 g (27.4 mmol) of chlorosulfonyl acetic acid methyl ester in 100 ml of dry dichloroethane. After crystallization from ether/hexane, 7.35 g=84.35% of the theoretical yield is obtained. Melting point 111°-112° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05130119 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-e66a9e9d905045f39c9a250f1f72d803 |
| Source note | uspto-grants-1992_07 |