反应详情

Analogously to the instructions for Example 9(a), 2.21 g (7 mmol) of 2-[N-(4-fluoro-3-trifluoromethyl-phenyl)sulfamoyl] acetic acid in dioxane is reacted with 1.13 g (7 mmol) of 2-hydroxy-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethylamine for about 1 hour at 90° C. After concentration by evaporation and crystallization from ethanol/ether, 2.87 g=92.3% of the theoretical yield is obtained as a crystallizate. Melting point 144°-146° C.

1. concentrationAfter concentration
2. customby evaporation and crystallization from ethanol/ether, 2.87 g=92.3% of the
3. customtheoretical yield
4. customis obtained as a crystallizate