HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]-benzoic acid-[2-hydroxy-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethylamide] → 4-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]-benzoic acid-(2,3,4-trihydroxybutyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]-benzoic acid-[2-hydroxy-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethylamide] | HCID 67899351 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | 4-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]-benzoic acid-(2,3,4-trihydroxybutyl)amide | HCID 19888173 | — |
Reaction Steps
Analogously to Example 1l(b), 3.8 g (7.5 mmol) of 4-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]-benzoic acid-[2-hydroxy-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethylamide] in methanol/water with cation exchanger is converted into the title compound. 1.74 g=83% of the theoretical yield is obtained as an amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05130119 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-dddff2b45d004d33866b330fe0003f13 |
| Source note | uspto-grants-1992_07 |