反应详情

Analogously to Example 22(a), 4.31 g (15 mmol) of 3-fluoro-6-(trifluoromethylsulfamoyl)-benzoic acid is reacted with 3.22 g (20 mmol) of 2-methylamino-1-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethanol and the crude product is purified by chromatography on silica gel with ethyl acetate/hexane. 4.93 g=76.3% of the theoretical yield is obtained as an amorphous solid.

1. customthe crude product is purified by chromatography on silica gel with ethyl acetate/hexane
2. custom4.93 g=76.3% of the theoretical yield
3. customis obtained as an amorphous solid