反应详情

1 g (0.0045 mol) of 6-hydroxy-5,6-dihydro-4-oxo -4H-pyrrol-o[1,2-a]thieno[2,3-f][1,4]diazepine is added in a single portion to an emulsion of 20 ml of acetone in 10 ml of 10N sodium hydroxide, and the reaction mixture is stirred vigorously at room temperature for 3 hours. The acetone is then removed under vacuum and 100 ml of water are poured onto the liquid residue. The yellow precipitate obtained is drained, washed with water and recrystallized. 0.7 g of 6-acetonyl-5,6-dihydro-4-oxo-4H -pyrrolo[1,2-a]thieno[2,3-f][1,4]diazepine is obtained in the form of white crystals, melting point 268° C. (isopropanol).

1. customThe acetone is then removed under vacuum and 100 ml of water
2. additionare poured onto the liquid residue
3. customThe yellow precipitate obtained
4. washwashed with water
5. customrecrystallized