Methyl Isocyanate → HCID 54552409, compound

HRID 654087Notes

Reaction equation

HRID 654087 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[NH2:5][C:6]1[CH:26]=[CH:25][C:9]([O:10][CH2:11][CH2:12][CH:13]2[CH2:16][N:15]([CH:17]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH3:18])[CH2:14]2)=[CH:8][CH:7]=1>C(Cl)(Cl)Cl>[CH3:1][NH:2][C:3]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([O:10][CH2:11][CH2:12][CH:13]2[CH2:14][N:15]([CH:17]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH3:18])[CH2:16]2)=[CH:25][CH:26]=1)=[O:4]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 19888359HCID 19888359, compound

Product 1

HCID 54552409HCID 54552409, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Under anhydous conditions, methyl isocyanate (10 mmol) is added dropwise to a stirred solution of 3-[2-(4-aminophenoxy)ethyl]-1-(1-phenylethyl)azetidine (10 mmol) in chloroform (100 ml). After stirring for 3 hr the solvent is removed and the residue purified by standard laboratory procedures.

Workup

  1. customis removed
  2. customthe residue purified by standard laboratory procedures

Sources & evidence

ORD record
ord-8096dac16f564681bf32575345521c30
Source dataset
uspto-grants-1992_07
Patent number
US05130309

Reaction notes

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