HCID 86745116, compound → HCID 19770791, compound

Participants

Reaction Steps

To a solution of isobutyl (E)-1-benzyloxycarbonyl-4-oxo-2-imidazolidineacrylate (7.7 g, 22.2 mmol) in 96% ethanol (200 ml), 5% palladium on charcoal (0.5 g) was added and hydrogen was bubbled at 20° C. and at atmospheric pressure for 2 hours. Removal of the catalyst and evaporation of the solvent gave a residue which was triturated with diisopropyl ether to give 4.1 g (86%) of the title compound, m.p. 50°-52° C. NMR (CDCl3): deltaH =4.45 (t, J=6 Hz, 1H, N--CH--N), 3.10 (s, 2 H, N--CH2 --CO). MS (E.I., 70 eV, 1.5 mA) m/z=214 (M+), 157 (M--C4H9 +, 85 (M--C7H13O2 +.

Provenance & Evidence