Ethyl levulinate → (3R,S)-3,7a-Dimethyl-2,5-dioxohexahydro-1 H-pyrrolo[1,2-a]imidazole

Participants

Reaction Steps

DL-Alaninamide hydrochloride (6.9 g), 0.055 mol) and ethyl 4-oxopentanoate (6.7 g, 0.043 mol) were reacted together according to the procedure of Example 2 to give the title compound, 1.65 g (22.8%), m.p 184°-192°. NMR (DMSO-d6 : deltaH =8.80 (bs, 1H, NH); 3.90 (q, J=7.5 Hz, 1H, CHCH3) 3.00-2.00 (c.a., 4H, CH2CH2); 1.42 (s, 3H, C--CH3); 1.22 (d, J=7.5 Hz, 1H, CHCH3)

Provenance & Evidence