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Chloroform → trans-2-Benzamido-cyclohexanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | (1R,2R)-2-Aminocyclohexanol | HCID 735777 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | trans-2-Benzamido-cyclohexanol | HCID 11020385 | — |
反応手順
(±)-trans-2-Aminocyclohexanol (241 gm) was combined with chloroform (2000 ml), water (2000 ml) and sodium bicarbonate (352 gm) and stirred. Benzoyl chloride (352 gm) was added dropwise to the stirred solution and stirring was continued for 1 hr. The product was filtered and washed with water. The white solid was dried at 80° C. to provide the product (mp 172°-173° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05130330 |
| 出典データセット | uspto-grants-1992_07 |
| ORD ID | ord-1e65e57980244259877bef49e9219abb |
| 出典メモ | uspto-grants-1992_07 |