HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 2-Methoxymethyl-2-methyl-6-cyano-4-chromanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Methoxyacetone | HCID 22172 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 3-Acetyl-4-hydroxybenzonitrile | HCID 12332832 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Methoxymethyl-2-methyl-6-cyano-4-chromanone | HCID 15056479 | — |
Reaction Steps
a mixture of 50 g of 3-acetyl-4-hydroxybenzonitrile, 70 ml of methoxy-2-propanone, 6 ml of pyrrolidine and 300 ml of toluene is boiled in a water separator for 3 hours. The mixture is evaporated, the residue is worked up in the customary manner (ethyl acetate/dil. hydrochloric acid) and 2-methoxymethyl-2-methyl-6-cyano-4-chromanone is obtained, m.p. 79°-81° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05130322 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-9562ccf88c7f43e1bc049adc16efce4c |
| Source note | uspto-grants-1992_07 |