Hydrochloric Acid → HCID 15056494, compound

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Reaction Steps

A mixture of 1 g of 2-methyl-2-(2-tetrahydropyranyloxymethyl)-4-(1,2-dihydro-2-oxo-1-pyridyl)-6-cyano-3-chroman [obtainable from 1-(2-tetrahydropyranyl)2-propanone via 2-methyl-2-(2-tetrahydropyranyloxymethyl)-6-cyano-4-chromanone, 2-methyl-2-(2-tetrahydropyranyloxymethyl)-6-cyano-4-chromanol, 2-methyl-2-(2-tetrahydropyranyloxymethyl)-6-cyano-3-chromene and the corresponding 3,4-epoxide] and 15 ml of 10% methanolic HCl solution is boiled for 15 min. Cooling and customary working up gives 2-hydroxymethyl-2-methyl-4-(1,2-dihydro2-oxo-1-pyridyl)-6-cyano-3-chromene. Example 5

Provenance & Evidence