HCID 19888587, compound → HCID 15056489, compound

HRID 654150Notes

Reaction equation

HRID 654150 reaction equation
[CH3:1][O:2][CH2:3][C:4]1([CH3:24])[CH:13]=[C:12]([N:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]2=[O:20])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:21](=[O:23])[NH2:22])[CH:10]=2)[O:5]1>[Pd]>[CH3:1][O:2][CH2:3][C:4]1([CH3:24])[CH2:13][CH:12]([N:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]2=[O:20])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:21](=[O:23])[NH2:22])[CH:10]=2)[O:5]1

Participants

3

Reactant 1

HCID 19888587HCID 19888587, compound

Product 1

HCID 15056489HCID 15056489, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A solution of 4 g of 2-methoxymethyl-2-methyl-4-(1,2-dihydro-2-oxo-1-pyridyl)-6-carbamoyl-3-chromene is hydrogenated on 4 g of 20% Pd-C at 20° C. and 1 bar in 200 ml of methanol, the mixture is filtered, the filtrate is evaporated and 2-methoxymethyl-2-methyl-4-(1,2-dihydro-2-oxo-1-pyridyl)-6-carbamoylchroman is obtained, m.p. 177°-179° C.

Workup

  1. filtration1 bar in 200 ml of methanol, the mixture is filtered
  2. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-255d801c25c54f369f44b42bd18bff2c
Source dataset
uspto-grants-1992_07
Patent number
US05130322

Reaction notes

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