HCID 19888560, compound → HCID 15056492, compound

HRID 654154Notes

Reaction equation

HRID 654154 reaction equation
[CH3:1][O:2][CH2:3][C:4]1([CH3:23])[CH:13]([OH:14])[CH:12]([N:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]2=[O:21])[C:11]2[C:6](=[CH:7][CH:8]=[C:9](Br)[CH:10]=2)[O:5]1>CO.[Pd]>[CH3:1][O:2][CH2:3][C:4]1([CH3:23])[CH:13]([OH:14])[CH:12]([N:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]2=[O:21])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[O:5]1

Participants

4

Reactant 1

HCID 19888560HCID 19888560, compound

Product 1

HCID 15056492HCID 15056492, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 280 mg of 2-methoxymethyl-2-methyl-4-(1,2-dihydro-2-oxo-1-pyridyl)-6-bromo-3-chromanol is hydrogenated on 140 mg of 20% Pd-C in 80 ml of methanol at 20° and 1 bar, the mixture is filtered, the filtrate is evaporated and 2-methoxymethyl-2-methyl-4-(1,2-dihydro-2-oxo-1-pyridyl)-3-chromanol m.p. 244°-246° C. is obtained after chromatographic purification on silica gel.

Workup

  1. filtration1 bar, the mixture is filtered
  2. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-7192de3ef48c4b5fb6ce5be50ed7d693
Source dataset
uspto-grants-1992_07
Patent number
US05130322

Reaction notes

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