反应详情

温度

50 °C

To a stirred solution of 12.55 parts of cis-4-amino-5-chloro-2-methoxy-N-(3-methoxy-4-piperidinyl)benzamide in 180 parts of N,N-dimethylformamide were added 5.05 parts of N,N-diethylethanamine and 3.4 parts of 2-chloroacetonitrile. The whole was stirred for 18 hours at 50° C. The solvent was evaporated. The residue was purified by column chromatography over silica gel using a mixture of trichloromethane and methanol (95:5 by volume) as eluent. The pure fractions were collected and the eluent was evaporated. The residue was triturated in 1,1'-oxybisethane. The product was filtered off and dried, yielding 12.21 parts (86.5%) of cis-4-amino-5-chloro-N-[1-(cyanomethyl)-3-methoxy-4-piperidinyl]-2-methoxybenzamide; mp. 130.4° C. (interm. 2).

1. customThe solvent was evaporated
2. customThe residue was purified by column chromatography over silica gel using
3. additiona mixture of trichloromethane and methanol (95:5 by volume) as eluent
4. customThe pure fractions were collected
5. customthe eluent was evaporated
6. customThe residue was triturated in 1,1'-oxybisethane
7. filtrationThe product was filtered off
8. customdried