2-[N-(4-Methanesulphonamidobenzyl)-N-methylamino]-5-methanesulphonamidoindane → 5-Methanesulphonamido-2-methylaminoindane

HRID 654198Notes

Reaction equation

HRID 654198 reaction equation
CS(NC1C=CC([CH2:10][N:11]([CH:13]2[CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([NH:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:19]=3)[CH2:14]2)C)=CC=1)(=O)=O>C(O)C.[Pd]>[CH3:26][S:23]([NH:22][C:18]1[CH:19]=[C:20]2[C:15](=[CH:16][CH:17]=1)[CH2:14][CH:13]([NH:11][CH3:10])[CH2:21]2)(=[O:25])=[O:24]

Participants

4

Reactant 1

HCID 150149922-[N-(4-Methanesulphonamidobenzyl)-N-methylamino]-5-methanesulphonamidoindane

Product 1

HCID 198886595-Methanesulphonamido-2-methylaminoindane

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-[N-(4-Methanesulphonamidobenzyl)-N-methylamino]-5-methanesulphonamidoindane (0.175 g) in ethanol (20 ml) containing 5% Pd/C (0.02 g) was stirred under a hydrogen atmosphere [275.8 kPa (40 p.s.i.)] for 31/2 hours at 40°. The catalyst was then removed by filtration and the filtrate evaporated to dryness in vacuo to give the title compound as an oil, yield 0.09 g, which was used directly without further purification.

Workup

  1. customThe catalyst was then removed by filtration
  2. customthe filtrate evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-0ddf747685334141ba61bfe760ca50e9
Source dataset
uspto-grants-1992_07
Patent number
US05130334

Reaction notes

Loading…