Sodium borohydride → HCID 15718590, compound

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Reaction Steps

The compound obtained in step (iii) above (16.2 g, 0.080 mol) is reduced with sodium borohydride (3.1 g, 0.082 mol) in absolute methanol (500 ml). The reaction mixture is concentrated under vacuum, ice-water is added thereto, the mixture is made acidic by the addition of concentrated hydrochloric acid and extracted with ethyl acetate. Upon evaporation of the solvent 2-cyano-5-methoxy-1,2,3,4-tetrahydro-1-naphthol (16.2 g) is obtained; m.p. 96°-98° C.

Provenance & Evidence