Hydrochloric Acid → HCID 19888684, compound

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Reaction Steps

A solution of the compound obtained in step (v) above (9.2 g, 0.05 mol) in anhydrous tetrahydrofuran (150 ml) is added dropwise to a mixture of lithium aluminum hydride (3.8 g, 0.1 mol) and anhydrous tetrahydrofuran (50 ml) under nitrogen atmosphere. The reaction mixture is heated to the reflux temperature for 4 hours, and then cooled. Water (40 ml) is added thereto and the reaction mixture is extracted with ethyl acetate (2×300 ml). The organic phase is dried over sodium sulfate, filtered and concentrated to dryness. The residue is then purified by flash chromatography eluting with methanol/ammonia 97/3. The hydrochloride is prepared by treating the thus obtained free base with HCl saturated isopropanol. The product of the title (9 g) is thus obtained; m.p.231°-232° C. (ethanol).

Provenance & Evidence