HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3,4-Dichlorophenyl)-2-hydroxyacetic acid → N-[(7-methoxy-1,2,3,4-tetrahydronaphth-2-yl) methyl]-3,4-dichloromandelamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3,4-Dichlorophenyl)-2-hydroxyacetic acid | HCID 221275 | — |
| Reactant | (7-Methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)methanamine | HCID 15718600 | — |
| Product | N-[(7-methoxy-1,2,3,4-tetrahydronaphth-2-yl) methyl]-3,4-dichloromandelamide | HCID 15718627 | 81.5% |
Reaction Steps
By following the procedure of Example 1(i) but starting from 3,4-dichloromandelic acid (3.1 g, 0.014 mol) and 2-aminomethyl-7-methoxy-1,2,3,4-tetrahydronaphthalene (2.67 g, 0.014 mol), N-[(7-methoxy-1,2,3,4-tetrahydronaphth-2-yl) methyl]-3,4-dichloromandelamide (4.5 g) is obtained as an oily product characterised by the following IR absorption maxima 3380 (b): O--H, CON--H; and 1641: NHC=0 cm-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05130339 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-22ee088bbeaa479aadbdeaed4f272c76 |
| Source note | uspto-grants-1992_07 |