Sodium Methoxide → HCID 131717462, compound

Participants

Reaction Conditions

Reaction Steps

Method A. To a suspension of diester diamide 10 (1.0 g, 3.16 mmol) in 6 mL of absolute MeOH was slowly added (~10 min) 1.8 mL of NaOMe (25% solution in absolute MeOH, 7.9 mmol) under argon at room temperature. The resulting colorless solution was heated at 60° C. for 4 hours and stirred at room temperature for 16 hours. The solvent was removed under reduced pressure, and the residual white solid was dissolved in 3 mL of H2O. The aqueous solution was acidified (concentrated HCl, pH ~2), and the colorless solid was filtered, washed with 5 mL of cold H2O followed by 5 mL EtOH, and dried; yield 0.54 g, (67%); mp 284°-285° C. dec; Anal. (C10H12N4O4) C, H, N.

Provenance & Evidence