Hexane → HCID 10024491, compound

Participants

Reaction Steps

Using the procedure of Example 8 but replacing the resultant compound of Example 7 with the resultant compound of Example 14 provided, after silica gel chromatography using 6:1 hexane:ethyl acetate, the desired compound (m.p. 84°-85° C., R 0.73, 2:1 hexane:ethyl acetate) in 90% yield. 1H NMR (CDCl3) 1.41 s, 9 H), 2.7-2.8 (m, 3 H), 3.01 (dd, J=14, 8 Hz, 1 H), 3.26 (q, J=7 Hz, 1 H), 3.61 (s, 3 H), 4.37 (m, 2 H), 5.42 (br d, 1 H), 5.56 (dd, J=15, 8 Hz, 1 H), 7.03-7.12 (m, 4 H), 7.2-7.3 (m, 6 H).

Provenance & Evidence