Tetrabutylammonium Fluoride → HCID 10088309, compound

Participants

Reaction Steps

A solution of 1.0 g (2.2 mmol) of the resultant compound of Example 18 in 8 ml of tetrahydrofuran was treated with 2.2 ml (2.2 mmol) of a 1.0M solution of tetra-n-butylammonium fluoride in tetrahydrofuran. After being stirred under N2 atmosphere at ambient temperature for 2 h, the solution was concentrated in vacuo, and the residue was partitioned between ethyl acetate and brine. The organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo. Chromatography of the residue on silica gel using 4:1 hexane:ethyl acetate provided 0.36 g (47%) of the desired compound.

Provenance & Evidence