HCID 14656853, compound → HCID 22844979, compound

HRID 654320Notes

Reaction equation

HRID 654320 reaction equation
[CH:1]([Mg]Cl)([CH3:3])[CH3:2].[C:6]([O:10][C:11]([NH:13][C@@H:14]([CH2:27][C:28]1[CH:33]=CC=C[CH:29]=1)[C@H:15](OS(C)(=O)=O)/[CH:16]=[CH:17]/[C:18]([O:20][CH3:21])=[O:19])=[O:12])([CH3:9])([CH3:8])[CH3:7].C(OC(N[C@@H](CC(C)C)[C@H](OS(C)(=O)=O)/C=C/C(OC)=O)=O)(C)(C)C>>[C:6]([O:10][C:11]([NH:13][C@@H:14]([CH2:27][CH:28]([CH3:29])[CH3:33])/[CH:15]=[CH:16]/[C@H:17]([C:18]([O:20][CH3:21])=[O:19])[CH:1]([CH3:3])[CH3:2])=[O:12])([CH3:7])([CH3:8])[CH3:9]

Participants

4

Reactant 3

HCID 14656853HCID 14656853, compoundHCID 131717466HCID 131717466, compoundHCID 178418918HCID 178418918, compound

Product 1

HCID 22844979HCID 22844979, compound

Procedure

Using the procedure of Example 8 but replacing benzylmagnesium chloride with isopropylmagnesium chloride and replacing the resultant compound of Example 7 with the resultant compound of Example 33 provided the desired compound.

Sources & evidence

ORD record
ord-2ccea215e326429d8bf076346b69c393
Source dataset
uspto-grants-1992_07
Patent number
US05130468

Reaction notes

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