2-Bromopropene → HCID 19888969, compound

Participants

Reaction Steps

To 2-bromopropene (4.53 g, 37.4 mmol) in 85 ml of dry THF at -78° C. was added t-butyllithium (44 ml of a 1.7M solution in pentane) dropwise. After 2 hours, 2-(2-propynylthio) benzaldehyde (3.0 g, 17.0 mmol) prepared according to the procedures described in Example 1, Steps A, B, and C in 30 ml of dry THF was added dropwise. The reaction mixture was allowed to warm up to room temperature (RT). The reaction mixture was quenched with 100 ml of a saturated NH4Cl solution, extracted twice with diethyl ether, washed with water and brine, and then dried over K2CO3 to afford the subtitle compound.

Provenance & Evidence