HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 2,6-diethyl-3-iodo-4(1H)-pyridone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-[(2-Ethyl-5,6,7,8-tetrahydroquinolin-4-yl)oxymethyl]phenylboronic acid | HCID 15171422 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,6-diethyl-3-iodo-4(1H)-pyridone | HCID 14950479 | 75.7% |
Reaction Steps
Iodine (720 mg) was added to a solution of compound C (430 mg) and sodium hydroxide (120 mg) in water (15 ml) and the mixture was stirred for 1 hour. The precipitated solid was collected by filtration and purified by flash chromatography, eluting with methanol/dichloromethane (1:19 v/v), to give 2,6-diethyl-3-iodo-4-(1H)-pyridone (D) (290 mg), m.p. 225°-227° C.; NMR (d6 -DMSO): 1.15(t,6H), 2.5(q,2H), 2.8(q,2H), 5.9(s,1H), 11.4(br s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05130318 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-7a45fdeb47f94efa90227a979fd0aac4 |
| Source note | uspto-grants-1992_07 |