HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidin-2-ylmethanol → 1-(2-Chlorophenylthiocarbamoyl)-2-hydroxymethylpiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidin-2-ylmethanol | HCID 94263 | — |
| Reactant | 1-Chloro-2-isothiocyanatobenzene | HCID 123171 | — |
| Catalyst | Triethylamine | HCID 8471 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(2-Chlorophenylthiocarbamoyl)-2-hydroxymethylpiperidine | HCID 19887182 | — |
Reaction Steps
3.4 g 2-Hydroxymethylpiperidine in 50 ml absolute tetrahydrofuran was treated with 1 drop of triethylamine and 5 g 2-chlorophenyl isothiocyanate. After 12 hours at room temperature, the reaction solution was cooled in an ice bath. The crystals were suction filtered and recrystallised from ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05131946 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-8616189f40e2434a86775450bfd36dcc |
| Source note | uspto-grants-1992_07 |