2-Bromopropane → HCID 14441918, compound

Participants

Reaction Steps

3.5 g 3-(4-Chloro-2-fluoro-5-hydroxyphenylimino)-1-methylhexahydro-3H-oxazolo[3,4-a]pyridine and 6.6 g potassium carbonate in 40 ml acetone was treated at room temperature with 3.1 g 2-bromopropane and heated under reflux for 6 hours. It was then treated again with 3.1 g 2-bromopropane and heated under reflux for 6 hours. After cooling the mixture was filtered, the filtrate concentrated and the residue purified by column chromatography (silica gel, eluent; hexane/ethyl acetate).

Provenance & Evidence