反应详情

In 40 ml of toluene, 2.6 g of 2-bromo-2-(4-fluorophenyl)acetyl chloride were gradually added dropwise at 20°-30° C. under stirring to 2.2 g of N-(2-butenyl)-N-(3-trifluoromethylphenyl)amine. After the reaction mixture was stirred for further 20 minutes, the precipitated insoluble matter was filtered off and 50 ml of toluene were added. The resulting toluene solution was washed twice with a saturated aqueous solution of sodium bicarbonate and twice with saturated saline. The toluene solution was dried over anhydrous sodium sulfate and then concentrated in an evaporator, whereby the intended compound was stoichiometrically obtained in an oily form.

1. filtrationthe precipitated insoluble matter was filtered off
2. addition50 ml of toluene were added
3. washThe resulting toluene solution was washed twice with a saturated aqueous solution of sodium bicarbonate and twice with saturated saline
4. dry with materialThe toluene solution was dried over anhydrous sodium sulfate
5. concentrationconcentrated in an evaporator, whereby the intended compound
6. customwas stoichiometrically obtained in an oily form