Water → HCID 88471420, compound

Participants

Reaction Conditions

Reaction Steps

350 mg of 17-(3-trimethylsilyl-prop-2-inyl)-17β-hydroxy-11β-(4-acetylphenyl)-4,9,15-estratrien-3-one is dissolved in methanol and stirred at 23° C. for 1.5 hours after addition of 387 mg of potassium carbonate. This is poured into water and extracted with acetic ester. The combined organic phases are dried over sodium sulphate and concentrated in vacuo. The residue is chromatographed with a mixture of hexane/acetic ester over silica gel. 205 mg of the title compound is isolated as white foam. Crystallisation from ether yields 176 mg of the title compound.

Provenance & Evidence