HCID 14819420, compound → HCID 14819421, compound

Participants

Reaction Steps

A solution of 1 g of 2,2-dimethyl-4-(2-oxo-1,2-dihydro-1-pyridyl)-6-nitro-1,2,3,4-tetrahydro-3-naphthol in 24 ml of methanol is hydrogenated at 20° and 1 bar over 0.5 g of 5% Pd-on-C until hydrogenation ceases. The mixture is filtered and evaporated and worked up in the customary manner (using dilute sodium hydroxide/methylene dichloride) to give 2,2-dimethyl-4-(2-oxo-1,2-dihydro-1-pyridyl)-6-amino-1,2,3,4-tetrahydro-3-naphthol.

Provenance & Evidence