Ammonium Chloride → HCID 19887350, compound

Participants

Reaction Steps

9.4 g of 1-(3,3-diphenyl-2-propenyl)-4-ethynyl-4-methylcarbamoyloxypiperidine are refluxed in 100 ml of 0.05 mol/liter ethanolic sodium ethoxide solution under argon for 3 hours. After cooling down, the alkoxide is decomposed by adding aqueous ammonium chloride solution and the solvent is distilled off under reduced pressure. After adding benzene and water to the residue, the benzene layer is separated and dried, then evaporated under reduced pressure. After recrystallizing the solid evaporation residue from ethanol, the title compound is obtained in 71.7% yield, m.p.: 126°-127° C.

Provenance & Evidence