4-Chlorophenyl Isocyanate → HCID 19887365, compound

Participants

Reaction Steps

A solution containing 5.8 g of 4-acetyl-1-[4,4-bis(4-fluorophenyl)-3-butenyl]-4-hydroxypiperidine and 7.0 g of 4-chlorophenyl isocyanate in 30 ml of tripropylamine is gently refluxed under argon while stirring for 3 hours, then the solvent is distilled off under reduced pressure. After adding benzene to the residue and filtering off the insoluble part, the benzene filtrate is filtered through a silica gel bed and evaporated under reduced pressure. The solid evaporation residue is recrystallized from ethanol under clarifying by activated carbon to obtain the title compound in 52% yield, m.p.: 186°-188° C.

Provenance & Evidence