HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl chloroformate → Benzyloxycarbonyl-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | Benzyloxycarbonyl-L-proline | HCID 101987 | — |
Reaction Steps
L-Proline 5 (100 gms, 0.87 moles) was dissolved in 2N sodium hydroxide (430 mL) and cooled in an ice bath. A further 220 mL of 4N sodium hydroxide was added simultaneously with benzyl chloroformate (155 gms, 0.90 moles) over 2 hrs. The reaction was then allowed to warm to room temperature overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05132301 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-557a042b66d6477799d1957c0f9f8ad4 |
| Source note | uspto-grants-1992_07 |