Acetic Anhydride → HCID 15171918, compound

HRID 654515Notes

Reaction equation

HRID 654515 reaction equation
[S:1]1[CH:5]=[C:4]([C:6]#[C:7][C:8]2([CH3:22])[CH2:13][CH2:12][C:11]3[C:14]([CH3:21])=[C:15]([OH:20])[C:16]([CH3:19])=[C:17]([CH3:18])[C:10]=3[O:9]2)[C:3]2[CH:23]=[CH:24][CH:25]=[CH:26][C:2]1=2.[C:27](OC(=O)C)(=[O:29])[CH3:28]>N1C=CC=CC=1>[C:27]([O:20][C:15]1[C:16]([CH3:19])=[C:17]([CH3:18])[C:10]2[O:9][C:8]([C:7]#[C:6][C:4]3[C:3]4[CH:23]=[CH:24][CH:25]=[CH:26][C:2]=4[S:1][CH:5]=3)([CH3:22])[CH2:13][CH2:12][C:11]=2[C:14]=1[CH3:21])(=[O:29])[CH3:28]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 15171818HCID 15171818, compound

Product 1

HCID 15171918HCID 15171918, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 0.3 g of rac-2-[(benzo[b]thiophen-3-yl)ethynyl]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol, 20 ml of pyridine and 1 ml of acetic anhydride was allowed to sit at room temperature over night and was then evaporated to dryness under reduced pressure. The residue was crystallized from hexane to yield 0.25 g of colorless crystals with m.p. 99°-101°.

Workup

  1. waitto sit at room temperature over night
  2. customwas then evaporated to dryness under reduced pressure
  3. customThe residue was crystallized from hexane

Sources & evidence

ORD record
ord-298a52b4130748eb9b6a993faaebaec3
Source dataset
uspto-grants-1992_07
Patent number
US05132310

Reaction notes

Loading…