Methanol → 2,4,5-Trifluoro-6-methoxyisophthalonitrile

HRID 65453Notes

Reaction equation

HRID 65453 reaction equation
[F:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([F:10])[C:5]([C:11]#[N:12])=[C:4](F)[C:3]=1[F:14].[CH3:15][OH:16]>>[F:10][C:6]1[C:7]([C:8]#[N:9])=[C:2]([F:1])[C:3]([F:14])=[C:4]([O:16][CH3:15])[C:5]=1[C:11]#[N:12]

Participants

3

Reactant 2

HCID 887MethanolHCID 608182Tetrafluoroisophthalonitrile

Product 1

HCID 135404452,4,5-Trifluoro-6-methoxyisophthalonitrile

Procedure

A 2.0 g amount of tetrafluoroisophthalonitrile was heated under reflux in 40 ml of methanol for 4 hours. The methanol was distilled off in vacuo to approximately one-fifth volume and ice water was then poured to the resultant mixture. The precipitated crystal was collected by filtration and was then washed with water and a small amount of cold methanol. After drying in vacuo, 1.6 g of the desired compound No. 20 was obtained.

Workup

  1. distillationThe methanol was distilled off in vacuo to approximately one-fifth volume and ice water
  2. additionwas then poured to the resultant mixture
  3. filtrationThe precipitated crystal was collected by filtration
  4. washwas then washed with water
  5. dry with materialAfter drying in vacuo, 1.6 g of the desired compound No
  6. custom20 was obtained

Sources & evidence

ORD record
ord-d98562553b3f49f6b58c599eed5929bd
Source dataset
uspto-grants-1986_09
Patent number
US04614742

Reaction notes

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