Methyl iodide → HCID 19761544, compound

HRID 654557Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([O:15][CH2:16][C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=2)[CH:5]=[C:6]([C:8]([O:13][CH3:14])([CH:10]([OH:12])[CH3:11])[CH3:9])[CH:7]=1.[CH3:27]I>>[CH3:27][O:12][CH:10]([CH3:11])[C:8]([C:6]1[CH:7]=[C:2]([F:1])[CH:3]=[C:4]([O:15][CH2:16][C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=2)[CH:5]=1)([O:13][CH3:14])[CH3:9]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 19761518HCID 19761518, compound

Product 1

HCID 19761544HCID 19761544, compoundYield 60%

Procedure

Using the procedure described in Example 8, (2RS,3SR)-2-(5-fluoro-3-(naphth-2-ylmethoxy)phenyl]-2-methoxybutan-3-ol was reacted with methyl iodide to give (2RS,3SR)-2-(5-fluoro-3-(naphth-2-ylmethoxy)phenyl]-2-methoxybut-3-yl methyl ether in 60% yield, m.p. 75°-76° C.

Sources & evidence

ORD record: ord-61350d35ba2b4f2191daa0848ff9ff61
Source dataset: uspto-grants-1992_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05132328

Reaction notes

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