Water → HCID 19088718, compound

HRID 654563Notes

Reaction equation

HRID 654563 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([O:14][C:15]1[CH:16]=[C:17]([C:22]([OH:29])([CH2:27][CH3:28])[C:23](OC)=[O:24])[CH:18]=[C:19]([F:21])[CH:20]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.O>C(OCC)C>[CH2:7]([O:14][C:15]1[CH:16]=[C:17]([C:22]([OH:29])([CH2:27][CH3:28])[CH2:23][OH:24])[CH:18]=[C:19]([F:21])[CH:20]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 962WaterHCID 19769486HCID 19769486, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19088718HCID 19088718, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Lithium aluminium hydride (0.345 g) was added to a solution of the ester so obtained in diethyl ether (70 ml) and the mixture was stirred at ambient temperature for 1 hour. Water (10 ml) was added dropwise and the mixture was filtered. The organic layer was dried (MgSO4) and evaporated to give (-)-2-(3-benzyloxy-5-fluorophenyl)butane-1,2-diol (2.2 g), as an oil.

Workup

  1. filtrationthe mixture was filtered
  2. dry with materialThe organic layer was dried (MgSO4)
  3. customevaporated

Sources & evidence

ORD record
ord-8f135711595f4cdf974730ebe9136e41
Source dataset
uspto-grants-1992_07
Patent number
US05132328

Reaction notes

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