HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromotrichloromethane → Ethyl 2-acetyl-2-bromobutyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromotrichloromethane | HCID 6383 | — |
| Reactant | Butanoic acid, 2-ethyl-3-oxo-, ethyl ester | HCID 79065 | — |
| Reactant | Tetrabutylammonium Fluoride Trihydrate | HCID 11726816 | — |
| Product | Ethyl 2-acetyl-2-bromobutyrate | HCID 11009975 | 56.5% |
Reaction Steps
In a 10 mL round-bottom flask, 1.58 g of ethyl 2-acetylbutyrate (10 mmol), 2.1 g bromotrichloromethane (10.5 mmol), and 200 mg of tetra-n-butylammonium fluoride trihydrate (0.632 mmol) were mixed at 24° C. for 1 h. Gas chromatographic analysis of the resulting mixture showed the presence of 1.34 g of ethyl 2-acetyl-2-bromobutyrate (56% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05132475 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-402593d179124bc695f6000a2107b035 |
| Source note | uspto-grants-1992_07 |